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Done with Singularity: White matter free water content at different stages of Alzheimer’s disease

We processed MRI data from the ADNIGO and ADNI2 databases with a state-of-the-art processing pipeline that uses T1 weighted (T1w), diffusion weighted (DW), and fluid-attenuated inversion recovery (FLAIR) scans to extract FW fractional volume in normal appearing white matter. We call this metric relative FW volume (rFW volume). We demonstrate for the first time that rFW volume in white matter is higher for subjects with greater cognitive impairments.

All processing was done using a Nextflowpipeline with all software dependencies bundled in a Singularity8 container ensuring quick and easy reproducibility of the results.

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